ea0098b12 | Basic Science | NANETS2023
Chen Weisheng
, Guenter Rachael
, Herring Brendon
, Golivi Yuvasri
, Whitt Jason
, Sammy Melissa
, Adams Cole
, Jaskula-Sztul Renata
, Chen Herbert
, Rose Bart
Background: Cancer cells utilize both oxidative phosphorylation (OXPHOS) and glycolysis to generate energy. Switching between OXPHOS and glycolysis can promote tumor progression. The mechanisms governing oncogenic metabolic flexibility are largely unknown, but recent data has suggested that Notch1 dysregulation in cancer cells can contribute to altered metabolic phenotypes. We hypothesized that Notch1 signaling supports metabolic flexibility in pancreatic neuroendocrine tumor ...